Neuromuscular Blocking Agents in Paediatric Patients: Influence of Age on the Response

Neuromuscular blocking agents in paediatric anaesthesia.

Neuromuscular blocking agents are used commonly in paediatric anaesthesia, both to facilitate tracheal intubation and during surgery. Paediatric patients differ from adults in certain pharmacokinetic and pharmacodynamic characteristics. However, because maturational changes in certain of these characteristics counterbalance, dosing requirements do not differ markedly with age. In general, onset...

The influence of certain ganglionic blocking agents on neuromuscular transmission.

GANGLIONIC blockade was first used to produce controlled hypotension during surgery by Scurr (1951). This technique has since become generally accepted in anaesthetic practice. Ganglion blocking drugs now available include the methonium compounds and the short acting agents trimetaphan and homatropinium (Trophenium). There is no doubt that these drugs act selectively on the sympathetic ganglia,...

The Influence of Certain Ganglionic Blocking Agents on Neuromuscular Transmission

GANGLIONIC blockade was first used to produce controlled hypotension during surgery by Scurr (1951). This technique has since become generally accepted in anaesthetic practice. Ganglion blocking drugs now available include the methonium compounds and the short acting agents trimetaphan and homatropinium (Trophenium). There is no doubt that these drugs act selectively on the sympathetic ganglia,...

tracheal intubation without the use of neuromuscular blocking agents

Neuromuscular Blocking Agents

• Neuromuscular blocking agents are used to improve conditions for tracheal intubation, to provide immobility during surgery, and to facilitate mechanical ventilation. • The main site of action of neuromuscular blocking agents (muscle relaxants) is on the nicotinic cholinergic receptor at the endplate of muscle. They also have effects at presynaptic receptors located on the nerve terminal. • Su...